Conference agenda
GDNA-2024: Genome Dynamics in Neuroscience and Aging

Organizers: Zhao-Qi Wang and Zhiheng Xu

Day 0 – June 8th 2024

16:00 Registration at the meeting venue/hotel

09:45 – 10:10Welcome and Opening Ceremony
Group Photo
SESSION I - Genome stability and aging(Chair: Youming Zhang, Ellen Nollen)
10:45: - 11:30Genome stability in aging and disease: New insights from C. elegansBjörn Schumacher(CECAD Cologne, DE)
11:30 - 11:55The NAD+-mitophagy axis in DNA repair and healthy longevityEvandro Fang(University of Oslo, NO)
11:55 – 12:20The longevity gene OSER1 mitigates oxidative stress and extends the lifespan across diverse speciesLene Rasmussen(University of Copenhagen, DK)
12:20 – 14:00Lunch
SESSION I – DNA damage and genome stability I(Chair: Lene Rasmussen, Xingzhi Xu)
14:00 - 14:25DNA strand break repair – proteins, structures and functionsStephen West(Cricks Institute, UK)
14:25 - 14:50Replication fork reversal and protectionJun Huang(Zhejiang University, CN)
14:50 - 15:05Short talk 1undetermined
15:05 – 15:30Primary microcephaly with an unstable genomeXingzhi Xu(Shenzhen University, CN)
15:30 – 16:00Café break
SESSION II – DNA damage and genome stability II(Chair: Lene Rasmussen, Xingzhi Xu)
16:00 - 16:25DNA damage by mechanical stressMarco Foiani(The AIRC Institute of Molecular Oncology, IT)
16:25 - 16:50Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apopGuomin Li(Chinese Institute for Medical Research Capital Me
16:50 - 17:15Activation of innate nucleic acid sensors by telomeric DNA and RNAJan Karlseder(Salk Institute for Biological Studies, USA)
17:15: - 17:40The role of SIRT6 in regulating genomic response to physical activity.Haim Cohen(Bar-Ilan University, IL)
17:40 - 17:55Short talk 2undetermined
17:55 – 18:10Short talk 3undetermined
18:10 - 18:35Identification of genetic vulnerabilities in aneuploid human cellsIan Hickson(University of Copenhagen, DK)
18:45Welcome receptionBalcony, Meeting Venue
SESSION III – DNA damage and neuropathies I(Chair: Yosef Shiloh, Tanya Paull)
09:00 - 09:45Understanding pathogenic DNA lesions in the developing and mature brainPeter McKinnon(St. Jude Children’s Research Hospital, USA)
09:45 – 10:10The role of Atm in cerebellar integrity and functionality.Ari Barzilai(Tel Aviv University, IL)
10:10 - 10:35Neuronal genome integrity.Andre Nussenzweig(National Institute of Health, USA)
10:35 – 11:05Café break
SESSION IV – DNA damage and neuropathies II(Chair: Yosef Shiloh, Tanya Paull)
11:05 - 11:30The genome instability-aging-senescence link: insights from ataxia-telangiectasiaYossi Shiloh(Tel Aviv University, IL)
11:30 - 11:55Differential responses of CNS cells to endogenous DNA damage.Laura Niedernhofer(University of Minnesota, USA)
11:55 - 12:20Mapping and characterizing the landscape of DNA double strand breaks in the human genomeRami Aqeilan(The Hebrew University, IL)
12:20 - 12:30Commercial 1undetermined
12:30 - 13:30Lunch
13:30 - 16:30Poster session
15:30 - 16:30Café served
SESSION V – DNA damage and neuropathies III(Chair: Bjorn Schumacher, Jiawei Zhou)
16:30 – 16:55Intersections between R-loop processing, DNA damage, and neurodegenerationTanya Paull(University of Texas at Austin, USA)
16:55 – 17:20DNA strand break repair and neurological diseaseKeith Caldecott(University of Sussex, UK)
17:20 – 17:35Short talk 4undetermined
17:35 – 17:50Short talk 5undetermined
17:50 – 18:15Differential functions of MRN in cerebellopathiesZhao-Qi Wang(Shandong University, CN)
18:30Invited Speaker’s dinnerTBD
SESSION VI - Aging and Neuropathies I(Chair: George Garinis, Ye Tian)
09:00 - 09:25Functional identification of PCDHA9 as a candidate gene for amyotrophic lateral sclerosis.Zhiheng Xu(Chinese Academy of Sciences, CN)
09:25 - 09:50Modifying protein toxicity in age-related neurodegenerative diseasesEllen Nollen(ERIBA, NL)
09:50 - 10:05Short talk 6undetermined
10:05 - 10:30The neural basis of healthy aging.Shiqing CaiChinese Academy of Sciences, CN)
10:30 - 11:00Café break
SESSION VI – Aging and Neuropathies II(Chair: George Garinis, Ye Tian)
11:00 - 11:25Glucose metabolism disorders and Alzheimer's diseaseZengqiang Yuan(Academy of Military Medical Sciences, CN)
11:25 - 11:50SIRT6 and Tau’s entangled roles in aging and neurodegenerationDeborah Toiber(Ben Gurion University, IL)
11:50 - 12:15Modulating neural stem cell fate and corticogenesis through lipid redox balance regulationZhongwei Zhou(Sun Yat-sen University, CN)
12:15 - 12:25Commercial 2undetermined
12:25 - 13:30Lunch
SESSION VII – Neurodegenerative process I(Chair: Deborah Toiber, Keith Caldecott)
13:30 - 13:55Specific dysfunction of mitochrondia directly contributes to the initiation and pregression of ALSXiangdong Fu(Westlake University, CN)
13:55 - 14:20The role of microglia-derived APOE particles in the pathogenesis of Alzheimer's diseaseHongsheng Zhang(Chongqing Medical University, CN)
14:20 - 14:35Short talk 7undetermined
14:35 - 14:50Short talk 8undetermined
14:50 - 15:05Short talk 9undetermined
15:05 - 15:30DNA damage signaling to mitochondria in neurodegeneration and agingVilhelm Bohr(University of Copenhagen, DK)
15:30 - 16:00Café break
SESSION VII – Neurodegenerative process II(Chair: Deborah Toiber, Keith Caldecott)
16:00 - 16:25Neuronal control of mitochondrial stress response: implications for aging and healthYe Tian(Chinese Academy of Sciences, CN)
16:25 - 16:50Intestinal epithelial dopamine receptor signaling drives sex-specific disease exacerbation in a mousJiawei Zhou(Chinese Academy of Sciences, CN)
16:50 - 17:05Short talk 10undetermined
17:05 - 17:20Short talk 11undetermined
17:20 - 17:35Short talk 12undetermined
17:35 - 17:50Short talk 13undetermined
17:50 – 18:15Epigenetic pathways in healthy aging and neurodegenerationRaffaella Nativio(Imperial College, UK)
18:30Gala Dinner – NetworkingHotel Restaurant
SESSION VIII - Aging I(Chair: Zhiheng Xu, Xiangdong Fu)
09:00 - 09:45Programming and reprogramming of agingGuanghui Liu(Chinese Academy of Sciences, CN)
09:45 - 10:10Transcription stress and telomere attrition during agingGeorge Garinis(IMBB-FORTH, GR)
10:10 - 10:35Stem cell aging and tissue regenerationZhenyu Ju(Jinan University, CN)
10:35 - 11:00Café break
SESSION VIII - Aging II(Chair: Zhiheng Xu, Xiangdong Fu)
11:00 - 11:25Lignoceric acid rejuvenates hematopoietic stem cellsBaohua Liu(Shenzhen University, CN)
11:25 - 11:40Short talk 14undetermined
11:40 - 11:55Short talk 15undetermined
11:55 – 12:20TBD -- Stem cell aging??Lorenz Studer(Memorial Sloan Kettering Cancer Center, USA)
12:20 - 12:30Poster AwardOrganizing Committee
12:30 - 12:40Closing remarksZhao-Qi Wang & Zhiheng Xu