Conference Chairperson:
Professor Le Kang
Organizers:
Professor Zhao-Qi Wang
Professor Zhiheng Xu
Organizing Committee:
George Garinis, Lene Rasmussen, Björn Schumacher, Yosef Shiloh, Deborah Toiber, Zhao-Qi Wang, Zhiheng Xu, Youming Zhang
Conference agenda
GDNA-2024: Genome Dynamics in Neuroscience and Aging
Organizers: Zhao-Qi Wang and Zhiheng Xu
Day 0 – June 8th 2024
16:00 Registration at the meeting venue/hotel
| Time | Topic | Speaker/Unit |
|---|---|---|
| 09:45 – 10:10 | Welcome and Opening Ceremony | |
| Group Photo | ||
| SESSION I - Genome stability and aging(Chair: Youming Zhang, Ellen Nollen) | ||
| 10:45: - 11:30 | Genome stability in aging and disease: New insights from C. elegans | Björn Schumacher(CECAD Cologne, DE) |
| 11:30 - 11:55 | The NAD+-mitophagy axis in DNA repair and healthy longevity | Evandro Fang(University of Oslo, NO) |
| 11:55 – 12:20 | The longevity gene OSER1 mitigates oxidative stress and extends the lifespan across diverse species | Lene Rasmussen(University of Copenhagen, DK) |
| 12:20 – 14:00 | Lunch | |
| SESSION I – DNA damage and genome stability I(Chair: Lene Rasmussen, Xingzhi Xu) | ||
| 14:00 - 14:25 | DNA strand break repair – proteins, structures and functions | Stephen West(Cricks Institute, UK) |
| 14:25 - 14:50 | Replication fork reversal and protection | Jun Huang(Zhejiang University, CN) |
| 14:50 - 15:05 | Short talk 1 | undetermined |
| 15:05 – 15:30 | Primary microcephaly with an unstable genome | Xingzhi Xu(Shenzhen University, CN) |
| 15:30 – 16:00 | Café break | |
| SESSION II – DNA damage and genome stability II(Chair: Lene Rasmussen, Xingzhi Xu) | ||
| 16:00 - 16:25 | DNA damage by mechanical stress | Marco Foiani(The AIRC Institute of Molecular Oncology, IT) |
| 16:25 - 16:50 | Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apop | Guomin Li(Chinese Institute for Medical Research Capital Me |
| 16:50 - 17:15 | Activation of innate nucleic acid sensors by telomeric DNA and RNA | Jan Karlseder(Salk Institute for Biological Studies, USA) |
| 17:15: - 17:40 | The role of SIRT6 in regulating genomic response to physical activity. | Haim Cohen(Bar-Ilan University, IL) |
| 17:40 - 17:55 | Short talk 2 | undetermined |
| 17:55 – 18:10 | Short talk 3 | undetermined |
| 18:10 - 18:35 | Identification of genetic vulnerabilities in aneuploid human cells | Ian Hickson(University of Copenhagen, DK) |
| 18:45 | Welcome reception | Balcony, Meeting Venue |
| Time | Topic | Speaker/Unit |
|---|---|---|
| SESSION III – DNA damage and neuropathies I(Chair: Yosef Shiloh, Tanya Paull) | ||
| 09:00 - 09:45 | Understanding pathogenic DNA lesions in the developing and mature brain | Peter McKinnon(St. Jude Children’s Research Hospital, USA) |
| 09:45 – 10:10 | The role of Atm in cerebellar integrity and functionality. | Ari Barzilai(Tel Aviv University, IL) |
| 10:10 - 10:35 | Neuronal genome integrity. | Andre Nussenzweig(National Institute of Health, USA) |
| 10:35 – 11:05 | Café break | |
| SESSION IV – DNA damage and neuropathies II(Chair: Yosef Shiloh, Tanya Paull) | ||
| 11:05 - 11:30 | The genome instability-aging-senescence link: insights from ataxia-telangiectasia | Yossi Shiloh(Tel Aviv University, IL) |
| 11:30 - 11:55 | Differential responses of CNS cells to endogenous DNA damage. | Laura Niedernhofer(University of Minnesota, USA) |
| 11:55 - 12:20 | Mapping and characterizing the landscape of DNA double strand breaks in the human genome | Rami Aqeilan(The Hebrew University, IL) |
| 12:20 - 12:30 | Commercial 1 | undetermined |
| 12:30 - 13:30 | Lunch | |
| POSTER SESSION | ||
| 13:30 - 16:30 | Poster session | |
| 15:30 - 16:30 | Café served | |
| SESSION V – DNA damage and neuropathies III(Chair: Bjorn Schumacher, Jiawei Zhou) | ||
| 16:30 – 16:55 | Intersections between R-loop processing, DNA damage, and neurodegeneration | Tanya Paull(University of Texas at Austin, USA) |
| 16:55 – 17:20 | DNA strand break repair and neurological disease | Keith Caldecott(University of Sussex, UK) |
| 17:20 – 17:35 | Short talk 4 | undetermined |
| 17:35 – 17:50 | Short talk 5 | undetermined |
| 17:50 – 18:15 | Differential functions of MRN in cerebellopathies | Zhao-Qi Wang(Shandong University, CN) |
| 18:30 | Invited Speaker’s dinner | TBD |
| Time | Topic | Speaker/Unit |
|---|---|---|
| SESSION VI - Aging and Neuropathies I(Chair: George Garinis, Ye Tian) | ||
| 09:00 - 09:25 | Functional identification of PCDHA9 as a candidate gene for amyotrophic lateral sclerosis. | Zhiheng Xu(Chinese Academy of Sciences, CN) |
| 09:25 - 09:50 | Modifying protein toxicity in age-related neurodegenerative diseases | Ellen Nollen(ERIBA, NL) |
| 09:50 - 10:05 | Short talk 6 | undetermined |
| 10:05 - 10:30 | The neural basis of healthy aging. | Shiqing CaiChinese Academy of Sciences, CN) |
| 10:30 - 11:00 | Café break | |
| SESSION VI – Aging and Neuropathies II(Chair: George Garinis, Ye Tian) | ||
| 11:00 - 11:25 | Glucose metabolism disorders and Alzheimer's disease | Zengqiang Yuan(Academy of Military Medical Sciences, CN) |
| 11:25 - 11:50 | SIRT6 and Tau’s entangled roles in aging and neurodegeneration | Deborah Toiber(Ben Gurion University, IL) |
| 11:50 - 12:15 | Modulating neural stem cell fate and corticogenesis through lipid redox balance regulation | Zhongwei Zhou(Sun Yat-sen University, CN) |
| 12:15 - 12:25 | Commercial 2 | undetermined |
| 12:25 - 13:30 | Lunch | |
| SESSION VII – Neurodegenerative process I(Chair: Deborah Toiber, Keith Caldecott) | ||
| 13:30 - 13:55 | Specific dysfunction of mitochrondia directly contributes to the initiation and pregression of ALS | Xiangdong Fu(Westlake University, CN) |
| 13:55 - 14:20 | The role of microglia-derived APOE particles in the pathogenesis of Alzheimer's disease | Hongsheng Zhang(Chongqing Medical University, CN) |
| 14:20 - 14:35 | Short talk 7 | undetermined |
| 14:35 - 14:50 | Short talk 8 | undetermined |
| 14:50 - 15:05 | Short talk 9 | undetermined |
| 15:05 - 15:30 | DNA damage signaling to mitochondria in neurodegeneration and aging | Vilhelm Bohr(University of Copenhagen, DK) |
| 15:30 - 16:00 | Café break | |
| SESSION VII – Neurodegenerative process II(Chair: Deborah Toiber, Keith Caldecott) | ||
| 16:00 - 16:25 | Neuronal control of mitochondrial stress response: implications for aging and health | Ye Tian(Chinese Academy of Sciences, CN) |
| 16:25 - 16:50 | Intestinal epithelial dopamine receptor signaling drives sex-specific disease exacerbation in a mous | Jiawei Zhou(Chinese Academy of Sciences, CN) |
| 16:50 - 17:05 | Short talk 10 | undetermined |
| 17:05 - 17:20 | Short talk 11 | undetermined |
| 17:20 - 17:35 | Short talk 12 | undetermined |
| 17:35 - 17:50 | Short talk 13 | undetermined |
| 17:50 – 18:15 | Epigenetic pathways in healthy aging and neurodegeneration | Raffaella Nativio(Imperial College, UK) |
| 18:30 | Gala Dinner – Networking | Hotel Restaurant |
| Time | Topic | Speaker/Unit |
|---|---|---|
| SESSION VIII - Aging I(Chair: Zhiheng Xu, Xiangdong Fu) | ||
| 09:00 - 09:45 | Programming and reprogramming of aging | Guanghui Liu(Chinese Academy of Sciences, CN) |
| 09:45 - 10:10 | Transcription stress and telomere attrition during aging | George Garinis(IMBB-FORTH, GR) |
| 10:10 - 10:35 | Stem cell aging and tissue regeneration | Zhenyu Ju(Jinan University, CN) |
| 10:35 - 11:00 | Café break | |
| SESSION VIII - Aging II(Chair: Zhiheng Xu, Xiangdong Fu) | ||
| 11:00 - 11:25 | Lignoceric acid rejuvenates hematopoietic stem cells | Baohua Liu(Shenzhen University, CN) |
| 11:25 - 11:40 | Short talk 14 | undetermined |
| 11:40 - 11:55 | Short talk 15 | undetermined |
| 11:55 – 12:20 | TBD -- Stem cell aging?? | Lorenz Studer(Memorial Sloan Kettering Cancer Center, USA) |
| 12:20 - 12:30 | Poster Award | Organizing Committee |
| 12:30 - 12:40 | Closing remarks | Zhao-Qi Wang & Zhiheng Xu |
| 12:40 | Departure | |